Alexandra Aubry Selected Research

Quinolones

2/2013	Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis.
4/2012	A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.
8/2010	Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
12/2006	Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones.
6/2006	Gatifloxacin derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase.
1/2006	Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
2/2005	Contribution of the ATP binding site of ParE to susceptibility to novobiocin and quinolones in Streptococcus pneumoniae.
4/2004	Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

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Alexandra Aubry Research Topics

Disease

23	Tuberculosis (Tuberculoses) 06/2021 - 10/2003
12	Infections 01/2022 - 08/2002
5	Ventilator-Associated Pneumonia 01/2020 - 08/2008
4	Leprosy (Hansen's Disease) 11/2021 - 05/2007
4	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2017 - 06/2006
4	Extensively Drug-Resistant Tuberculosis 01/2016 - 08/2010
3	Buruli Ulcer 01/2020 - 07/2009
2	Body Weight (Weight, Body) 10/2021 - 01/2018
1	Coinfection 01/2020
1	Enterobacteriaceae Infections 05/2019
1	Bacterial Infections (Bacterial Infection) 01/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Critical Illness (Critically Ill) 01/2018
1	Skin Diseases (Skin Disease) 01/2017
1	Tularemia 01/2017
1	Hypersensitivity (Allergy) 02/2005
1	Infection with Mycobacterium marinum 08/2002

Drug/Important Bio-Agent (IBA)

13	FluoroquinolonesIBA 11/2021 - 01/2006
11	Rifampin (Rifampicin)FDA LinkGeneric 01/2022 - 10/2003
10	DNA GyraseIBA 11/2013 - 04/2004
9	Pharmaceutical PreparationsIBA 01/2022 - 11/2006
9	Anti-Bacterial Agents (Antibiotics)IBA 10/2021 - 08/2002
8	QuinolonesIBA 02/2013 - 04/2004
7	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 09/2006
5	Moxifloxacin (Avelox)FDA Link 05/2020 - 11/2010
4	Isoniazid (Ftivazide)FDA LinkGeneric 06/2021 - 10/2003
4	Streptomycin (Streptomycin Sulfate)FDA Link 01/2020 - 07/2009
4	Amikacin (A.M.K)FDA LinkGeneric 01/2018 - 11/2015
2	bedaquiline (R207910)IBA 01/2022 - 01/2020
2	Ciprofloxacin (Cipro)FDA LinkGeneric 10/2021 - 05/2020
2	Levofloxacin (Levaquin)FDA Link 05/2020 - 01/2017
2	Pyrazinamide FDA LinkGeneric 01/2020 - 11/2006
2	Clarithromycin (Biaxin)FDA LinkGeneric 01/2020 - 11/2015
2	Carbapenems (Carbapenem Antibiotics)IBA 05/2019 - 01/2016
2	Capreomycin (Capastat)FDA Link 01/2017 - 01/2016
2	Kanamycin FDA Link 01/2017 - 01/2016
2	Doripenem FDA Link 01/2016 - 01/2014
2	Imipenem FDA Link 01/2016 - 01/2014
2	Meropenem (Merrem)FDA LinkGeneric 01/2016 - 01/2014
2	Ofloxacin (Ofloxacine)FDA LinkGeneric 03/2015 - 11/2010
2	AminoglycosidesIBA 11/2010 - 05/2010
1	rifapentine (Priftin)FDA Link 01/2020
1	dolutegravirIBA 01/2020
1	Clofazimine (Lamprene)FDA Link 01/2020
1	16S Ribosomal RNAIBA 01/2019
1	Anti-Infective Agents (Microbicides)IBA 01/2017
1	AcidsIBA 01/2015
1	HoloenzymesIBA 11/2013
1	Dapsone FDA Link 11/2013
1	4-hydroxyphenylisopropylarterenol (CC 25)IBA 02/2013
1	Colistin (Coly-Mycin)FDA Link 12/2012
1	Catalytic DNA (Deoxyribozyme)IBA 08/2010
1	Ethambutol (Myambutol)FDA LinkGeneric 05/2010
1	Cyclic PeptidesIBA 05/2010
1	EnzymesIBA 03/2009
1	ProcalcitoninIBA 08/2008
1	Adenosine Triphosphate (ATP)IBA 02/2005
1	Novobiocin (Streptonivicin)FDA Link 02/2005
1	DNA Topoisomerase IV (Topoisomerase IV)IBA 02/2005
1	Pipemidic Acid (Palin)IBA 04/2004
1	Nalidixic Acid FDA Link 04/2004
1	Gatifloxacin (Zymar)FDA Link 04/2004
1	Proteins (Proteins, Gene)FDA Link 04/2004

Therapy/Procedure

4	Therapeutics 01/2020 - 08/2002
3	Injections 01/2020 - 01/2016
2	Extracorporeal Membrane Oxygenation 01/2018 - 01/2018
1	Cannula 01/2018
1	Drug Therapy (Chemotherapy) 11/2006
1	Duration of Therapy 11/2006